翻訳と辞書 Words near each other ・ L-Galactose ・ L-galactose 1-dehydrogenase ・ L-Glucose ・ L-glutamate oxidase ・ L-glutamyl-(BtrI acyl-carrier protein) decarboxylase ・ L-glycol dehydrogenase ・ L-group ・ L-gulonate 3-dehydrogenase ・ L-gulonolactone oxidase ・ L-Għanja tal-Poplu ・ L-iditol 2-dehydrogenase ・ L-idonate 5-dehydrogenase ・ L-imħabba ・ L-infinity ・ L-Innu Malti ・ L-isoaspartyl methyltransferase ・ L-kick ・ L-KO Kompany ・ L-lactate dehydrogenase (cytochrome) ・ L-lysine 6-monooxygenase (NADPH) ・ L-lysine 6-oxidase ・ L-lysine 6-transaminase ・ L-lysine cyclodeaminase ・ L-lysine oxidase ・ L-lysine-lactamase ・ L-Men of The Year ・ L-methionine (R)-S-oxide reductase ・ L-methionine (S)-S-oxide reductase ・ L-mimosine synthase ・ L-moment Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク L-isoaspartyl methyltransferase ： ウィキペディア英語版 L-isoaspartyl methyltransferase Protein L-isoaspartyl methyltransferase (PIMT, PCMT), also called S-adenosyl-L-methionine:protein-L-isoaspartate O-methyltransferase, is an enzyme which recognizes and catalyzes the repair of damaged L-isoaspartyl and D-aspartatyl groups in proteins. It is a highly conserved enzyme which is present in nearly all eukaryotes, archaebacteria, and Gram-negative eubacteria.〔 ==Function== PIMT acts to transfer methyl groups from S-adenosyl-L-methionine to the alpha side chain carboxyl groups of damaged L-isoaspartyl and D-aspartatyl amino acids. The enzyme takes the end methyl residue from the methionine side chain and adds it to the side chain carboxyl group of L-isoaspartate or D-aspartate to create a methyl ester. Subsequent nonenzymatic reactions result in a rapid transformation to L-succinimide, which is a precursor to aspartate and isoaspartate. The L-succinimide can then undergo nonenzymatic hydrolysis, which generates some repaired L-aspartyl residues as well as some L-isoaspartyl residues, which can then enter the cycle again for eventual conversion to the normal peptide linkage. PIMT tends to act on proteins that have been non-enzymatically damaged due to age. By performing this repair mechanism, the enzyme helps to maintain overall protein integrity. This mechanism has been observed by several groups, and has been confirmed through experimental testing. In one report, PIMT was inhibited by adenosine dialdehyde. The results supported the proposed function of the enzyme, as the amount of abnormal L-aspartate residues increased when cells were treated with the indirect inhibitor, adenosine dialdehyde. Additionally, S-adenosylhomocysteine is known to be a competitive inhibitor of PIMT.〔 When PIMT is not present in cells, the abnormal aspartyl residues accumulate, creating abnormal proteins that have been known to cause fatal progressive epilepsy in mice. It has been suggested that calmodulin may play a role in stimulating the function of PIMT, although the relationship between these two molecules has not been thoroughly explored. In addition to calmodulin, guanosine 5'-O-()triphosphate (GTPgammaS) has been found to stimulate PIMT activity. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「L-isoaspartyl methyltransferase」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.